Polyclonal Rabbit anti-caspase-1 (C-Terminal)

Conjugate: Purified

Immunogen: A 16 amino acid peptide located near human Caspase-1 carboxy terminus.

Concentration: 1.0 mg/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: Rabbit anti Human Caspase-1 antibody recognizes an epitope within the C-terminal region (CT) of human Caspase-1, otherwise known as IL-1Beta converting enzyme. Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to C. elegans cell death gene (ced-3).Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. Regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases (Ghayur et al. 1997).Rabbit anti Human Caspase-1 antibody detects a cleaved subunit band of approximately 21 kDa in human heart cell lysates (predicted precursor MWT 45.2kDa).

• Artikelnummer: SANPS297
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: PS297
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Klonalität: Polyclonal
• Methode: Immunohistochemistry (paraffin), Western Blotting
• Wirt: Rabbit
• Konjugat: Conjugated