Product Type: Inhibitor
CAS No.: 172889-26-8
MolecularFormula: C16H19N5
Molecular Weight: 281,4
Source: Synthetic
Purity: ≥ 98% (TLC)
Solubility: Soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol
Appearance: Tan solid
PubChem CID: 1400
Scientific Background: PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. This has a range of effects and implications. Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases. PP1 displays > 8000-fold selectivity over ZAP-70 and JAK2.
References: 1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701.2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.