Product Type: Inhibitor
CAS No.: 172889-27-9
MolecularFormula: C15H16ClN5
Molecular Weight: 301,8
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (25mg/mL); or ethanol (3mg/mL, warm)
Appearance: Off-white solid
PubChem CID: 4878
Scientific Background: PP2 is a selective inhibitor of Src-family tyrosine kinases. PP2 has been shown to inhibit Lck, FynT, and phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). PP2 displays > 10000-fold selectivity over ZAP-70 and JAK2.
References: 1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701.2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.