Protein Tyrosine Phosphatase, non-receptor type 6(CPTC-PTPN6-2), 1mg/mL

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Description: PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1 ) from follicular lymphomas (SHP-1 negative). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: CPTC-PTPN6-2

Entrez Gene ID: 5777

Immunogen: Recombinant human full-length PTPN6 protein

• Artikelnummer: BTMBNUM2259-50
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUM2259-50
• Verpackungseinheit: 50 uL
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Isotyp: IgG2a kappa
• Wirt: Mouse
• Konjugat: Unconjugated