Purified Anti-Human CD8a Antibody(HIT8a), Mouse, Monoclonal

Abbreviation: CD8a

Target Synonym: T-cell surface glycoprotein CD8 alpha chain;CD8A;T8;Leu2;MAL;

Conjugation: Unconjugated

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Clone NO.: HIT8a

UNIProt ID: P01732

Background: CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3?domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

Concentration: 0.5 mg/mL

• Artikelnummer: ELSE-AB-F1271A-25
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-F1271A-25
• Green Labware: Nein
• Verpackungseinheit: 25 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Methode: Flow Cytometry
• Isotyp: Mouse IgG1 κ
• Human Gene ID: 925
• Wirt: Mouse