Product Type: Inhibitor
CAS No.: 1160514-60-2
MolecularFormula: C16H11Cl3F3N3O3
Molecular Weight: 456,63
Source: Synthetic
Purity: >98%
Solubility: Soluble to 100 mM in DMSO
Appearance: White Solid
PubChem CID: 56964346
Scientific Background: Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1).
References: 1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.