Product Type: Inducer
CAS No.: 303-45-7
MolecularFormula: C30H30O8
Molecular Weight: 518,56
Source: Synthetic
Purity: >98%
Solubility: Soluble to 25 mM in ethanol and in DMSO.
Appearance: Dark Yellow Solid
PubChem CID: 3503
Scientific Background: Gossypol is a natural phenol derived from the cotton plant, and is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. It has proapoptotic properties, due to the regulation of the Bax and Bcl2. It also reversibly inhibits calcineurin and binds to calmodulin (1, 2).
References: 1. www.bioscreening.net “Gossypol”2. Carruthers N.J., Dowd M.K., and Stemmer P.M. (2007) Eur J Pharmacol. 555(2-3): 106-114.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.