Rabbit anti Human Calcium Channel

Rabbit anti Human Calcium Channel, Polyclonal, IgG

Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3.

Positive Control: Rat brain lysate.

Immunogen: Synthetic peptide derived from the rat beta3 calcium channel conjugated to KLH.

Purification Method: Ammonium Sulfate Precipitation.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

References: 1. Castellano,A.et.al., Cloning and expression of a third calcium channel beta subunit
J. Biol. Chem. 268 (5), 3450-3455 (1993

2. Castellano,Aet.al. Cloning and expression of a neuronal calcium channel beta subunit
J. Biol. Chem. 268 (17), 12359-12366 (1993)

3. Smith SM, et al.Neuronal voltage-activated calcium channels: on the roles of the alpha 1E and beta 3 subunits.Ann N Y Acad Sci USA 868, 175-198 (1999).

UniProt: P54284.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX1515P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X1515P
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit