Rabbit anti Human Caveolin 1

Rabbit anti Human Caveolin 1, Polyclonal, IgG

Background: Caveolin 1 is a tyrosine phosphoprotein that plays an essential role in the formation of caveolae where it acts as a scaffolding protein. It has also been shown to bind cholesterol and to be involved in the lipid transport, membrane trafficking and signal transduction. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

Immunogen: Synthetic peptide derived from the human caveolin-1 beta isoform.

Purification Method: Ammonium Sulfate Precipitation.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

References: 1. Cai, T., et al. 'Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase.' J. Cell Biol. 2008, 182, 1153-1169.

2. Dittman, K., et al. 'Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.' Mol. Cancer 2008, 7, 69.

3. Zhong, Y., et al. 'Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling.' J. Neurosci. 2008, 28, 7788-7796.

4. Tourkina, E., et al. 'Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo.' Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 294, L843-L861

5. Huang, J.H., et al. 'Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1.' J. Biol. Chem. 2007, 282, 6143-6152.

UniProt: Q03135.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX1863P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X1863P
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit