Rabbit anti Human Cysteine string protein (CSP) Alpha, DNAJC5 alpha

Rabbit anti Human Cysteine string protein (CSP) Alpha, DNAJC5 alpha, Polyclonal, IgG

Background: May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. The amino terminus of CSP contains the J domain, a consensus sequence found on a DnaJ like protein which is a member of the heatshock protein family. Since heat shock proteins serve as chaperones that participate in protein folding and protein complex formation, CSP is believed to perform similar functions in the assembly of synaptic vesicle proteins which are essential to membrane trafficking. Evidence for a role of CSP in presynaptic neurotransmitter release has come from genetic and physiological study in which the Drosophila CSP null mutant fails to elicit synaptic potential upon high frequency stimulation. CSP null mutants have a lethal phenotype and for the small percentage of mutant flies that survive, they become paralyzed and die at elevated temperature.

Positive Control: Human brain; Expressed in tissue of pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.

Immunogen: Synthetic peptide derived from the human CSP protein.

Purification Method: Ammonium Sulfate Precipitation.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

References: 1. Coppola T., Gundersen C., Widespread expression of human cysteine string proteins.
FEBS Lett. 391:269-272(1996) [PubMed: 8764987] [Abstract].

UniProt: Q9H3Z4.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX2406P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X2406P
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Western Blotting, ELISA
• Isotyp: IgG
• Wirt: Rabbit