Rabbit anti Mouse Focal Adhesion Kinase (FAK)

Rabbit anti Mouse Focal Adhesion Kinase (FAK), Polyclonal, IgG

Background: Focal Adhesion Kinase (FAK) is a 120 kDa tyrosine kinase which become phosphorylated in response to oncogene- and extracellular-matrix integrin-dependent stimulation. Chicken, mouse and human FAK has been isolated and the deduced amino acid sequences showed identity of over 90%. It is expressed in embryonic stem cells, and ubiquitously throughout development, in all adult tissues examined and in many cell lines. The highest expression of FAK is seen in the brain, testes and in osteoclasts. It is distinct from other non-receptor protein tyrosine kinases in that its catalytic domain is flanked by amino- and carboxy-terminal domains of about 400 amino acids each. Also, it does not contain the Src homology 2 or 3 domains, which mediate protein-protein interaction, nor a myristylation site that anchors proteins to the membrane.

Immunogen: Bacterially expressed fusion protein consisting of the C-terminal 150 amino acids of the mouse FAK.

Purification Method: Ammonium Sulfate Precipitation.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

References: 1. Hanks, S.K., et al. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Natl. Acad. Sci. USA 1992, 89, 8487-8491

2. Ilic, D., et al. Focal adhesion kinase: at the crossroads of signal transduction. J. Cell Sci. 1997, 110, 401-407.

UniProt: P34152.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX1215P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X1215P
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Polyclonal
• Methode: Immunoprecipitation, Western Blotting
• Isotyp: IgG
• Wirt: Rabbit