Rat anti-Mouse Interleukin 6, clone MP5-32C11 (Monoclonal)

Clone Number: MP5-32C11

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 100 ug/ml

Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide

Additional info: The antibody neutralizes mouse interleukin 6 (IL-6). It does not cross-react with LPS (the component of the bacterial cell wall which is considered responsible for the toxicity of gram-negative bacteria) and TNFalpha nor does it block human or rat IL-6 in proliferation assays using the KD83 cell line. MP5-32C11 inhibits mouse IL-6-induced proliferation of the NFS60 myelomonocytic cell line and KD83 plasmacytoma. IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe infection and regulates the immune response, acute phase reaction and haematopoiesis. IL-6 plays a critical role in Bcell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis of plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of antibodyproducing hybridomas.

References: Takatsuki et al. J Immunol 1988;141:3072/McKenzie et al. J Immunol 1988;141:2907/van Snick et al. Annu Rev Immunol 1990;8:253

• Artikelnummer: SANMON5017
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON5017
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunoprecipitation, Western Blotting, ELISA, Functional Assay
• Isotyp: IgG2a
• Wirt: Rat