Recombinant Human APC protein (His tag)

Abbreviation: APC

Target Synonym: Adenomatous polyposis coli protein;APC;Deleted in polyposis 2.5

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P25054

Background: APC is a ubiquitous, tumor-suppressor protein that is mutated in most colon cancers, generally resulting in a gene product that is truncated in the carboxy terminal region. APC contains several binding domains. The region used as an immunogen overlaps the EB1, DLG (PDZ sequence), and PSD-93 domains. These domains bind microtubules, mitotic spindles, and F-actin and are involved in cell cycle, division, and migration. The immunogen does not include the beta -catenin-binding region, which antagonizes Wnt signaling. The human APC amino acid sequence used as immunogen is 83% and 86% identical to mouse and rat APC, respectively.

Sequence: Pro 2712-Val 2843

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEH100301-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEH100301-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK