Recombinant Human Calnexin/CANX protein (His tag)

Abbreviation: Calnexin;CANX

Target Synonym: Calnexin;IP90;Major Histocompatibility Complex Class I Antigen-Binding Protein p88;p90;CANX

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: P27824

Background: Calnexin/CANX is a single-pass type I membrane protein which belongs to the calreticulin family. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin is a calcium-binding protein that interacts briefly with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. Calnexin seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Calnexin dwindles with aging and might contribute to a cytoprotection in an array of human age-related diseases.

Sequence: Met1-Pro481

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDMH100065-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMH100065-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK