Recombinant Human IGFBP1 Protein(Trx Tag)

Protein Tag: N-Trx

Uniprot: P08833

Accession: P08833

Background: IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth-promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP1 has an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. The binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Bio Acitivity: Not validated for activity

Sequence: Ala26-Asn259

Purity: > 95% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Endotoxin: < 10 EU/mg of the protein as determined by the LAL method

Calculated MW: 44 kDa

Observed MW: 48 kDa

• Artikelnummer: ELSPDEH100473-500
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: PDEH100473-500
• Verpackungseinheit: 500μg
• Mengeneinheit: STK
• Reaktivität: Human
• Wirt: Escherichia Coli