Recombinant Human IgG1 Fc protein

Abbreviation: IgG1 Fc

Target Synonym: Ig gamma-1 chain C region;Ig gamma-1 chain C region EU;Ig gamma-1 chain C region KOL;Ig gamma-1 chain C region NIE

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: P01857

Background: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens.The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.Mediates IgG effector functions on monocytes triggering ADCC of virus-infected cells.

Sequence: Glu99-Lys330

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDMH100032-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMH100032-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK