Recombinant Human KI67 protein(His tag)

Abbreviation: KI67

Target Synonym: Antigen identified by monoclonal antibody Ki-67;Antigen KI-67;Antigen Ki67

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P46013

Background: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly.Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface.Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility.Binds DNA, with a preference for supercoiled DNA and AT-rich DNA.Does not contribute to the internal structure of mitotic chromosomes.May play a role in chromatin organization.It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Sequence: Lys1001-Pro1112

Purity: > 85 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEH100099-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEH100099-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK