Recombinant Human P-glycoprotein1/ABCB1 protein (His tag)

Abbreviation: P-glycoprotein1;ABCB1

Target Synonym: ATP-dependent translocase ABCB1;ABCB1;ATP-binding cassette sub-family B member 1;P-glycoprotein 1;Phospholipid transporter ABCB1;CD243;

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P08183

Background: Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218, PubMed:35970996).Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203).Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218, PubMed:35970996).

Sequence: Leu 392-Met 628

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEH100361-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEH100361-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK