Recombinant Human S100A1 Protein(Sumo Tag)

Protein Tag: N-Sumo

Uniprot: P23297

Accession: P23297

Background: Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole.

Bio Acitivity: Not validated for activity

Sequence: Met1-Ser94

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 10 EU/mg of the protein as determined by the LAL method.

Calculated MW: 28.19 kDa

Observed MW: 30 kDa

• Artikelnummer: ELSPDEH100559-500
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: PDEH100559-500
• Verpackungseinheit: 500μg
• Mengeneinheit: STK
• Reaktivität: Human
• Wirt: Escherichia Coli