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Recombinant Human SIGLEC2/CD22 Protein (His Tag)
Recombinant Human SIGLEC2/CD22 Protein (His Tag)
Artikelnummer
ELSPDMH100024-20
Verpackungseinheit
20 µg
Hersteller
Elabscience Biotechnology
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Abbreviation: SIGLEC2;CD22
Target Synonym: B-cell receptor CD22;BL-CAM;B-lymphocyte cell adhesion molecule;CD22 antigenMGC130020;CD22 molecule;CD22;sialic acid binding Ig-like lectin 2;Siglec-2;SIGLEC2FLJ22814;T-cell surface antigen Leu-14;SIGLEC-2;Siglec-2
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-His
UNIProt ID: P20273
Background: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Sequence: Asp20-Arg687
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method.
Target Synonym: B-cell receptor CD22;BL-CAM;B-lymphocyte cell adhesion molecule;CD22 antigenMGC130020;CD22 molecule;CD22;sialic acid binding Ig-like lectin 2;Siglec-2;SIGLEC2FLJ22814;T-cell surface antigen Leu-14;SIGLEC-2;Siglec-2
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-His
UNIProt ID: P20273
Background: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Sequence: Asp20-Arg687
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method.
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