Recombinant Mouse CD62L/L-Selectin protein (His tag)

Abbreviation: CD62L;L-Selectin

Target Synonym: L-selectin;Sell;CD62 antigen-like family member L;Leukocyte adhesion molecule 1;LECAM1;Lymph node homing receptor;Lymphocyte antigen 22;CD62L;LECAM-1;Lnhr;Ly-22;Ly-m22;Lyam-1;Lyam1

Target Species: Mouse

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P18337

Background: L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.

Sequence: Trp 39-Asn 332

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEM100101-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEM100101-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK