Recombinant Mouse FGA/Fibrinogen A protein (His tag)

Abbreviation: FGA;Fibrinogen A

Target Synonym: FGA;Fib2;Fibrinogen A;Fibrinogen alpha chain;Fibrinogen Type I;fibrinogen;A alpha polypeptide;FPA

Target Species: Mouse

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: E9PV24

Background: Fibrinogen is a 340 kDa, secreted glycoprotein complex that is found in blood at concentrations of 150-400 mg/dL. It is secreted primarily by hepatocytes, but is also reported to be expressed by fibroblasts, type I alveolar epithelium, intestinal epithelium and some tumor cells. Fibrinogen is a homodimer that is composed of two, three-polypeptide chain subunits. Fibrinogen plays a central role in clot formation. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Fibrinogen is also a component of the ECM and binds to cell surface molecules on inflammatory cells. Mature mouse alpha, beta and gamma -chains share 67%, 85% and 83% aa identity with human alpha, beta and gamma -chains, respectively.

Sequence: Asp 434-Gln 789

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEM100087-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEM100087-20
• Green Labware: Nein
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK