Recombinant Mouse TIMP-2/TIMP2 protein (His tag)

Abbreviation: TIMP-2;TIMP2

Target Synonym: CSC-21Ktissue inhibitor of metalloproteinase 2;metalloproteinase inhibitor 2;TIMP metalloproteinase inhibitor 2;Tissue inhibitor of metalloproteinase 2.

Target Species: Mouse

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P25785

Background: Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP-1, TIMP-2, TIMP-3, and TIMP-4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.And the interaction with MMP-14 facilitates the activation of pro-MMP-2.It has been shown that the binding of TIMP 2 to a3b1 integrin results in the inhibition of endothelial cell proliferation and angiogenesis.

Sequence: Cys 27-Pro 220

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEM100090-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEM100090-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK