Recombinant Rabbit IL10 protein(His tag)

Abbreviation: IL-10

Target Synonym: IL-10;Cytokine synthesis inhibitory factor;CSIF;IL 10

Target Species: Rabbit

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: Q9TSJ4

Background: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation.In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.

Sequence: Met1-Ser178

Purity: > 80 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDMO100002-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMO100002-20
• Green Labware: Nein
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK