Recombinant Rat ANG2 protein (His tag)

Abbreviation: ANG2

Target Synonym: AGPT2;ANG2;ANG-2;angiopoietin 2;Angiopoietin-2;angiopoietin-2a;angiopoietin-2B;angiopoitin 2;ANGPT2;Tie2-ligand

Target Species: Rat

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: O35462

Background: Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of either Ang-1 or full-length Ang-2 to Tie-2. Ang-2 functions as a pro-angiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.

Sequence: Tyr 19-Val 204

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDER100038-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDER100038-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK