Recombinant Rat CD80/B7-1 protein (His tag)

Abbreviation: CD80;B7-1

Target Synonym: T-lymphocyte activation antigen CD80;Activation B7-1 antigen;B7;CD80;Cd28l;Ly-53;Ly53;MIC17;TSA1

Target Species: Rat

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: G3V671

Background: The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

Sequence: Gly 41-Ala 262

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDER100068-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDER100068-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK