Recombinant Rat EZH1 protein (His tag)

Abbreviation: EZH1

Target Synonym: Enhancer of zeste homolog 1;ENX2;Histone-lysine N-methyltransferase EZH1

Target Species: Rat

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: F1LZH3

Background: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Sequence: Lys 201-Ser 400

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDER100059-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDER100059-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK