Recombinant Rat Syndecan-1/SDC1 Protein (His Tag)

Abbreviation: Syndecan-1;SDC1

Target Synonym: SDC1;Synd1;CD138

Target Species: Rat

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: P26260

Background: Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

Sequence: Met1-Lys253

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method.

• Artikelnummer: ELSPDMR100001-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMR100001-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK