Recombinant Rhinopithecus roxellana IGF1/IGF‑I/IGF-1 protein (His tag)

Recombinant Rhinopithecus roxellana IGF1/IGF‑I/IGF-1 protein (His tag)
Artikelnummer
ELSPDEC100005-500
Verpackungseinheit
500μg
Hersteller
Elabscience Biotechnology

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Protein Tag: N-His

Uniprot: Q68LC0

Accession: Q68LC0

Background: IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation.

Bio Acitivity: Not validated for activity

Sequence: Gly 49-Met 153

Purity: > 95% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 10 EU/mg of the protein as determined by the LAL method.

Calculated MW: 11.4 kDa

Observed MW: 13 kDa
Mehr Informationen
Artikelnummer ELSPDEC100005-500
Hersteller Elabscience Biotechnology
Hersteller Artikelnummer PDEC100005-500
Verpackungseinheit 500μg
Mengeneinheit STK
Reaktivität Various species
Wirt Escherichia Coli
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