Rottlerin, CAS 82-08-6

Autophagy inducer

Product Type: Inducer

CAS No.: 82-08-6

MolecularFormula: C30H28O8

Molecular Weight: 516,55

Source: Synthetic

Purity: ≥98%

Solubility: Soluble to 2 mM in ethanol and to 20 mM in DMSO.

Appearance: Orange to brown solid.

PubChem CID: 5281847

Scientific Background: Rottlerin has been shown to inhibit protein kinase C as well as CAM kinase III. It is also a potent activator of many K+ channels which are Ca2+-activated. Studies have illustrated Rottlerin to act as a mitochondrial uncoupler which depolarizes membrane potential. Lastly, Rottlerin can induce autophagy by inhibition of mTORC1 signalling.

References: 1. Gschwendt M. et al. (1994) Biochem Biophys Res Commun. 199(1): 93-8.2. Wu S., et al. (2007) J Cell Physiol. 210(3): 655-66.3. Soltoff S. (2001) J Biol Chem. 276(41): 37986-92.4. Balgi A., et al. (2009) PLoS One. 4(9): e7124.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-394-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-394-50MG
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK