Safinamide, CAS 133865-89-1

MAO-B Inhibitor

Product Type: Inhibitor

CAS No.: 133865-89-1

MolecularFormula: C17H19FN2O2

Molecular Weight: 302,3

Source: Synthetic

Purity: >98% (HPLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (50 mg/ml)

Appearance: White powder

PubChem CID: 131682

Scientific Background: A selective and reversible inhibitor of monoamine oxidase B (MAO-B, IC50=98 nM with greater than 100-fold selectivity over MAO-A) (1). It displays anticonvulsant activity (2) and protects against kainate-induced seizures and hippocampal neurodegeneration in rat models (3). Reduces overactive glutamatergic signaling via use-dependent sodium channel blockade (4). A novel therapeutic for Parkinson’s disease with multiple modes of action (5). Effective as an add-on to dopamine agonist therapy in early Parkinson’s Disease(6).

References: 1. MS Strolin Benedetti et al. 1994 J. Pharm. Pharmacol. 46:8142. RG Fariello et al. 1998 J. Pharmacol. Exp. Ther. 285:3973. R Maj et al.1998 Eur. J. Pharmacol. 8 359:274. F Gardoni et al. 2018 J. Pharmacol. Exp. Ther. 2018 367:4425. C Caccia et al. 2006 Neurology 67(7 Suppl. 2):S186. AH Schapira et al. 2013 Eur. J. Neurol. 20:271

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-625-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-625-5MG
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK