SB203580, CAS 152121-47-6

p38 MAP kinase inhibitor

Product Type: Inhibitor

CAS No.: 152121-47-6

MolecularFormula: C21H16FN3OS

Molecular Weight: 377,4

Source: Synthetic

Purity: ≥98% (HPLC)

Solubility: Soluble in DMSO (50 mg/ml)

Appearance: White to off-white powder

PubChem CID: 176155

Scientific Background: SB203580 is a a pyridinyl imidazole that inhibits p38 MAP kinase. SB 203580 has also been shown to inhibit heat shock protein 27 (HSP 27) phosphorylation and has been shown to induce the activation of Raf-1. It displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. SB203580 is cell permeable.

References: 1. Hall-Jackson C. A., Goedert M., Hedge P., & Cohen P. (1999) Oncogene. 18(12): 2047–2054.2. Saklatvala, J., et al. (1996) J. Bio. Chem. 271(12): 6586–6589.3. Cuenda A., et al. (1995) FEBS Letters. 364(2): 229–233.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-474-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-474-25MG
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK