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Set8 Chemiluminescent Assay Kit
Set8 Chemiluminescent Assay Kit
Artikelnummer
BPS82244
Verpackungseinheit
96 reactions
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Applications: Study enzyme kinetics and screen small molecule inhibitors for drug discovery and high throughput screening (HTS) applications.
Background: SET8 (PR/SET domain containing protein 8), also known as KMT5A (lysine-specific methylates 5A), belongs to the family of proteins that contain an SET domain. It has the specificity of being the only protein that monomethylates H4K20me1, but also participates in monomethylating proteins like p53 and PCNA (proliferating cell nuclear antigen). It is involved in cell cycle regulation and DNA replication and repair. Abnormal expression of SET8 can lead to cancer, and this protein is found at high levels in several cancers, such as breast cancer. Inhibition of SET8 was found to increase cancer cell sensitivity to radiotherapy. The use of inhibitors alone or in combinatory therapy promises to bring benefits in cancer therapy.
Contraindications: The Set8 Chemiluminescent Assay Kit is compatible with up to 1% final DMSO concentration. Avoid the use of strong acids and bases, ionic detergents and high salt concentrations.
Description: The Set8 Chemiluminescent Assay Kit is an ELISA (enzyme-linked immunosorbent assay)-based assay designed to measure the histone methylase activity of Set8 (SET domain containing lysine methyltransferase 8) for screening and profiling applications. The Set8 assay kit comes in a convenient 96-well format, with enough recombinant purified Set8 enzyme (amino acids 195-252), substrate, antibodies, and all the reagents necessary for detection.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed
Uniprot: Q9NQR1
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
References: Pan D., et al., 2022 Biomed Environ Sci 35(3), 194:205
Applications: Study enzyme kinetics and screen small molecule inhibitors for drug discovery and high throughput screening (HTS) applications.
Background: SET8 (PR/SET domain containing protein 8), also known as KMT5A (lysine-specific methylates 5A), belongs to the family of proteins that contain an SET domain. It has the specificity of being the only protein that monomethylates H4K20me1, but also participates in monomethylating proteins like p53 and PCNA (proliferating cell nuclear antigen). It is involved in cell cycle regulation and DNA replication and repair. Abnormal expression of SET8 can lead to cancer, and this protein is found at high levels in several cancers, such as breast cancer. Inhibition of SET8 was found to increase cancer cell sensitivity to radiotherapy. The use of inhibitors alone or in combinatory therapy promises to bring benefits in cancer therapy.
Contraindications: The Set8 Chemiluminescent Assay Kit is compatible with up to 1% final DMSO concentration. Avoid the use of strong acids and bases, ionic detergents and high salt concentrations.
Description: The Set8 Chemiluminescent Assay Kit is an ELISA (enzyme-linked immunosorbent assay)-based assay designed to measure the histone methylase activity of Set8 (SET domain containing lysine methyltransferase 8) for screening and profiling applications. The Set8 assay kit comes in a convenient 96-well format, with enough recombinant purified Set8 enzyme (amino acids 195-252), substrate, antibodies, and all the reagents necessary for detection.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed
Uniprot: Q9NQR1
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
References: Pan D., et al., 2022 Biomed Environ Sci 35(3), 194:205
| Artikelnummer | BPS82244 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 82244 |
| Verpackungseinheit | 96 reactions |
| Mengeneinheit | PAK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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