Abbreviation: SH3PXD2A
Target Synonym: SH3PXD2A;FISH;SH3MD1;TKS5
Conjugation: Unconjugated
UNIProt ID: Q5TCZ1
Background: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs, NADPH oxidases (NOXs and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human SH3PXD2A
Dilution: WB 1:500-1:2000,IF 1:50-1:200