English
Sheep anti Rat SSeCKS - myristylated (PKC) substrate
Sheep anti Rat SSeCKS - myristylated (PKC) substrate, Polyclonal, IgG
Artikelnummer
EXAS125P
Verpackungseinheit
250 µg
Hersteller
Exalpha Biologicals Inc
Verfügbarkeit:
wird geladen...
Preis wird geladen...
Background: Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicated during the process of spermiogenesis and in the actin-based stellate morphology of mesangial cells.
Positive Control: Rat aortic smooth muscle.
Purification Method: Ammonium Sulfate Precipitation.
Source: Sheep were immunized with a recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.
References: 1. Lin, X., et al. 'A novel src- and ras-suppressed protein kinase C substrate with cytoskeletal architecture.' J. Biol. Chem. 1996, 271, 28430-28438
2. Siegel, S.M., et al. 'SSeCKS immunolabeling in rat primary sensory neurons.' Brain Res. 2002, 926, 126-136
3. Nelson, P.J., et al. 'Involvement of the protein kinase C substrate, SSeCKS, in the actin-based stellate morphology of mesangial cells.' J. Cell. Sci. 1999, 112, 361-370.
UniProt: Q62766 (Rat).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Positive Control: Rat aortic smooth muscle.
Purification Method: Ammonium Sulfate Precipitation.
Source: Sheep were immunized with a recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.
References: 1. Lin, X., et al. 'A novel src- and ras-suppressed protein kinase C substrate with cytoskeletal architecture.' J. Biol. Chem. 1996, 271, 28430-28438
2. Siegel, S.M., et al. 'SSeCKS immunolabeling in rat primary sensory neurons.' Brain Res. 2002, 926, 126-136
3. Nelson, P.J., et al. 'Involvement of the protein kinase C substrate, SSeCKS, in the actin-based stellate morphology of mesangial cells.' J. Cell. Sci. 1999, 112, 361-370.
UniProt: Q62766 (Rat).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
| Artikelnummer | EXAS125P |
|---|---|
| Hersteller | Exalpha Biologicals Inc |
| Hersteller Artikelnummer | S125P |
| Green Labware | Nein |
| Verpackungseinheit | 250 µg |
| Mengeneinheit | STK |
| Reaktivität | Rat (Rattus) |
| Klonalität | Polyclonal |
| Methode | Immunoprecipitation, Western Blotting, Immunohistochemistry |
| Isotyp | IgG |
| Wirt | Sheep |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
Verwandte Artikel
Markieren Sie die Artikel, um Sie dem Warenkorb hinzuzufügen oder
Immer für Sie da
Gernot Ensinger, M.Sc.
