SIGLEC1 / CD169 / Sialoadhesin(HSn 7D2), 1mg/mL

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Description: Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1, 709 amino acid protein, also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant, encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: HSn 7D2

Entrez Gene ID: 6614

Immunogen: Fc fusion protein containing N-terminal 4 domains of human sialoadhesin.

Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)/IHC (FFPE) (published for clone)/WB (published for clone)

Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/IHC, FFPE (published)/WB (published)

• Artikelnummer: BTMBNUM2843-50
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUM2843-50
• Verpackungseinheit: 50 uL
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting, Flow Cytometry, Immunohistochemistry, Functional Studies
• Isotyp: IgG1 kappa
• Wirt: Mouse
• Konjugat: Unconjugated