Product Type: Inhibitor
CAS No.: 130495-35-1
MolecularFormula: C22H26N2O3.HCl
Molecular Weight: 402,92
Source: Synthetic
Purity: >98%
Solubility: Soluble to 100 mM in water
Appearance: White solid
PubChem CID: 104956
Scientific Background: SKF-96365 is a selective inhibitor of receptor mediated Ca2+ entry and voltage-gated Ca2+ entry (1). It has also been shown o inhibit cytochrome P-450 mediated reactions (1,2), and reversibly activates non-selective cation channels in human endotherlial cells (1,3).
References: 1. Leis H.J., et al. (1995) Br J Pharmacol. 114(3): 598-601.2. Sheets J.J., Mason J.I., Wise C.A. and Eastabrook R.W. (1986) Biochem Pharmacol. 35: 487-491.3. Schwarz G., Droogmans G. and Nilius B. (1994) Cell Calcium. 15: 45-54.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.