Sodium/hydrogen exchanger 1

Background: NHE-1 is involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. NHE-1 plays an important role in signal transduction. Located in the kidney and intestine.

Positive Control: Protein expressed in kidney and intestine.

Immunogen: Synthetic peptide derived from the human NHE-1 protein.

Formulation: Provided as solution in phosphate buffered saline.

References: 1. Pang, T., et al. 'Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger.; J. Biol. Chem. 277:43771-43777(2002).

2. Slepkov, E.R., et al. 'Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1.; Biochem. J. 379:31-38(2004).

3. Slepkov, E.R., et al. 'Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger.; J. Biol. Chem. 280:17863-17872(2005).

UniProt: P19634.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX2339B
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X2339B
• Green Labware: Nein
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Methode: Western Blotting
• Wirt: Rabbit