Target Synonym: SORD;HEL-S-95n;SORD1
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
Buffer: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Immunogen: Recombinant fusion protein of human Sorbitol Dehydrogenase
Dilution: WB 1:500-1:2000
Calculated MW: 10kDa/38kDa
Observed MW: 38kDa
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