SP600125, CAS 129-56-6

Jnk inhibitor

Product Type: Inhibitor

CAS No.: 129-56-6

MolecularFormula: C14H8N2O

Molecular Weight: 220,2

Source: Synthetic

Purity: >98%

Solubility: Soluble in DMSO or methanol

Appearance: Yellow to brown solid

PubChem CID: 8515

Scientific Background: Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 µM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis.

References: 1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6. 2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63.3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204.4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-381-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-381-50MG
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK