Product Type: Inhibitor
CAS No.: 123-78-4
MolecularFormula: C18H37NO2
Molecular Weight: 299,49
Source: Synthetic
Purity: >98%
Solubility: Soluble to 100 mM in DMSO
Appearance: Solid
PubChem CID: 5280335
Scientific Background: Sphingosine can be phosphorylated in vivo via two kinases which leads to the formation of a potent signaling lipid. It is a selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. It also inhibits calmodulin-dependent enzymes and is the precursor of ceramide.
References: 1. Radin N. (2003) Biochem J. 371(Pt2): 243-256.2. Carter H.E., Glick F.J., Norris W.P., Phillips G.E. (1947) J Biol Chem. 170: 285-295.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.