ST1936, CAS 1210-81-7

Formulation: A solid

Formal Name: 5-chloro-N,N,2-trimethyl-1H-indole-3-ethanamine

Purity: ≥98%

Formula Markup: C13H17ClN2

Formula Weight: 236,7

Shelf life (days): 1460

CAS Number: 1210-81-7

Notes: ST1936 is an agonist of the serotonin (5-HT) receptor subtype 5-HT6.{66562,66563} It selectively binds to 5-HT6 (Ki = 31 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A, and the serotonin transporter (SERT; Kis = >1,000 nM for all) but also binds to the 5-HT7 receptor (Ki = 168 nM).{66562} ST1936 induces cAMP accumulation in BHK fibroblasts (EC50 = 16 nM).{66563} It decreases the basal firing rate of dopaminergic neurons in the ventral tegmental area but not substantia nigra pars compacta in rats in a dose-dependent manner.{66564} ST1936 (10 and 30 mg/kg) prevents stress-induced decreases in vanilla sugar-sustained appetitive behavior, indicating anti-anhedonic-like activity, in rats.{66565} It induces self-administration in rats when administered at a dose of 1 mg/kg.{66566}

• Artikelnummer: CAY39811-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39811-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK