Stromal Cell-Derived Factor-1 beta (CXCL12), mouse recombinant (rmSDF-1b)

Kategorie: Cytokines

Formulation: lyophilized

Storage: -20°C

Weight: 8513 D

Description: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase (By similarity). (www.uniprot.org) Produced in E.coli as a non-glycosylated, polypeptide chain containing 72 amino acids. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development.

• Artikelnummer: BOL94864.2
• Hersteller: Biomol
• Hersteller Artikelnummer: 94864.2
• Green Labware: Nein
• Verpackungseinheit: 2 µg
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Wirt: Escherichia Coli