Product Description: Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC50 value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines[1].
Applications: Cancer-Kinase/protease
Formula: C85H116F3N19O15
References: [1]Baggio C, Udompholkul P, Gambini L, Pellecchia M. Targefrin: A Potent Agent Targeting the Ligand Binding Domain of EphA2. J Med Chem. 2022 Nov 4.
CAS Number: 3031514-44-7
Molecular Weight: 1700.94
Compound Purity: 99.45
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Ephrin Receptor