Temozolomide, CAS 85622-93-1

AGT inhibitor

Product Type: Inhibitor

CAS No.: 85622-93-1

MolecularFormula: C6H6N6O2

Molecular Weight: 194,2

Source: Synthetic

Purity: ≥99% (TLC); NMR(Conforms)

Solubility: Soluble in DMSO (25 mg/ml, warm) or water (weakly)

Appearance: Off white powder

PubChem CID: 5394

Scientific Background: Temozolomide is a membrane permeable DNA alkylating agent which acts as an anti-tumor and anti-angiogenic agent by alkylating the N-7 or O-6 positions of guanine residues which triggers tumor cell death (1-2). It has been used clinically as an anti-cancer agent (3) and has been found to induce autophagy in a variety of cell lines (4).

References: 1. Kurzen H., et al. (2003) Anticancer Drugs. 14: 515.2. Gunther W., et al. (2003) Br. J. Cancer. 88: 463.3. Danson S.J., et al. (2001) Expert Rev. Anticancer Ther. 10: 13.4. Natsumeda M., et al. (2011) Neuropathology. 31: 486.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-363-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-363-25MG
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK