Product Type: Inhibitor
CAS No.: 50-35-1
MolecularFormula: C13H10N2O4
Molecular Weight: 258,2
Source: Synthetic
Purity: >98%
Solubility: Soluble in 5 mg/ml DMSO
Appearance: White Solid
PubChem CID: 5426
Scientific Background: Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Caution: Teratogenic.
References: 1. Ito T., et al. (2010) Science. 327:1345.2. Weglicki W.B., et al. (1993) Mol. Cell. Biochem. 129:195.3. D'Amato R.J., et al. (1994) Proc. Natl. Acad. Sci. USA. 91:4082.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.