Thiolutin, CAS 87-11-6

RNA polymerase inhibitor

Product Type: Inhibitor

CAS No.: 87-11-6

MolecularFormula: C8H8N2O2S2

Molecular Weight: 228,3

Source: Synthetic

Purity: ≥98% (TLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (15 mg/ml)

Appearance: Yellow powder

PubChem CID: 6870

Scientific Background: Thiolutin is a sulfur antibiotic. Studies show the potential transcriptional inhibition on yeast degradation. By calculating the mRNA decay rates of transcription at different times after inhibition, it was evident that the effect of Thiolutin on the various degradation pathways of mRNA compromises the stability of the mRNA and the mechanism of gene expression (1). In pharmacology is known to inhibit endothelial cell adhesion by perturbing Hsp 27 interactions with components of the actin and intermediate filament cytoskeleton (2). Studies shown the inhibition of tumor cell-induced angionegesis in vivo, adhesion of endothelial cells to vitronectin ( IC50=0.83 µM) (3). Potentially inhibits developmental angiogenesis in zebrafish (2). Cell permeable. Active in vivo. Looking for more information on HSP27? Visit our new HSP27 Scientific Resource Guide at http://www.HSP27.com.

References: 1. Pelechano V. and Perez-Ortin J. (2008) Yeast 25: 85-92.2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165.3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-375-1MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-375-1MG
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK