Thyroglobulin antibody (2H11 + 6E1)

Clone Name: 2H11 + 6E1

Light Chain: Kappa

Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 305

Positive Control: Thyroid

Specificity/Sensitivity: Clone [2H11 + 6E1] cocktail is especially designed for sensitive detection of thyroglobulin. It stains thyroglobulin in follicular epithelial cells as well as colloid tissue.

Form: Liquid

Buffer (with preservative): Tissue culture supernatant diluted in Tris-HCl buffer, 0.2% BSA, 0.09% Sodium azide.

Concentration:

Background: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

Uniprot ID: P01266

Antigen Species: Human

Immunogen: Purified human thyroglobulin

Purification: unpurified

Conjugation: Unconjugated

Full Name: thyroglobulin

• Artikelnummer: GTX01838-500
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX01838-500
• Green Labware: Nein
• Verpackungseinheit: 500 μl
• Mengeneinheit: STK
• Reaktivität: Human, Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin), Western Blotting
• Isotyp: IgG1
• Human Gene ID: 7038
• Wirt: Mouse