Trichostatin A, CAS 58880-19-6

HDAC inhibitor

Product Type: Inhibitor

CAS No.: 58880-19-6

MolecularFormula: C17H22N2O3

Molecular Weight: 302,37

Source: Synthetic

Purity: >98%

Solubility: Soluble to 10 mM in ethanol and to 50 mM in DMSO

Appearance: Beige Solid

PubChem CID: 444732

Scientific Background: Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression but interfering with the removal of acetyl groups thereby altering the ability of DNA transcription factors to access the DNA inside chromatin (2). It also has anti-cancer properties (3).

References: 1. Vanhaecke T., Papeleu P., Elaut G., Rogiers V. (2004) Curr Med Chem. 11(12): 1629-1643.2. Yoshida, et al. (1990) J Biol Chem. 165: 17174.3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-254-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-254-5MG
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK