Trimetazidine-d8 (hydrochloride), CAS 1219795-37-5

Formulation: A solid

Formal Name: 1-(2,3,4-trimethoxybenzyl)piperazine-2,2,3,3,5,5,6,6-d8, dihydrochloride

Purity: ≥99% deuterated forms (d1-d8)

Formula Markup: C14H14D8N2O3 • 2HCl

Formula Weight: 347,3

Shelf life (days): 1460

CAS Number: 1219795-37-5

Notes: Trimetazidine-d8 is intended for use as an internal standard for the quantification of trimetazidine by GC- or LC-MS. Trimetazidine is a cardioprotective agent.{51477} It decreases ischemia-reperfusion injury-induced pyroptosis in H9c2 rat cardiomyocytes when used at concentrations ranging from 5 to 100 µM. In vivo, trimetazidine (10 mg/kg) reduces cardiac TNF-α and cardiac troponin I (CTnI) levels, improves left ventricular ejection fraction, and increases survival in a rat model of ventricular fibrillation-induced post-resuscitation myocardial dysfunction.{51478} Trimetazidine (20 mg/kg) increases overall survival, prevents neuromuscular junction degeneration, and delays motor function decline in an SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS).{51479} Formulations containing trimetazidine have been used in the treatment of angina.

• Artikelnummer: CAY39810-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39810-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung